Capsiplex Burn is a unique fat-burning supplement that targets three main areas to assist weight loss: energy, metabolism, and cravings. Its formula focuses on two proprietary ingredients – Innoslim and Capsimax. Innoslim is the least recognizable of the two being a ginseng compound.
Which is particularly interesting for a fat burner as it’s mostly made from ginseng, which typically speaking is usually in muscle building supplements rather than fat burners. Although it would have some benefits for weight loss, specifically in a thermogenic fat burner.
As for Capsimax, that’s a pretty standard affair and whilst it does boost metabolism slightly, and help burn fat, it’s generally not one of the better ingredients to aid weight loss overall.
The real sticking point is that Capsiplex Burn uses Chromium and Capsimax to help regulate appetite. Unfortunately, there are much better options here, like 5HTP and Glucomannan. However, if you’re having no issues controlling hunger whilst in a caloric deficit, and you just want to take something to raise your metabolism and energy levels then Capsiplex is ultimately a good option.
The doses are pretty decent and Capsiplex also contains a good amount of B vitamins and caffeine for energy. (There’s quite a lot of caffeine in here, so if you’re sensitive to caffeine this one definitely is not for you).
This one is more for people having trouble shifting the last couple of pounds rather than a fat burner for your entire weight loss journey. Due to it’s low score on appetite suppression, we wouldn’t recommend it for anyone really pushing the envelope on body fat percentages, but if you’re looking for something to speed up weight loss, or push the last hurdle it’s a good choice and one of the better options. But, there are better fat burning options to help most people lose weight.
Capsiplex is pretty new, so it’s not necessarily a bad sign that there aren’t many verified customer reviews of capsiplex burn out there. We found a few on reddit, tiktok and Instagram that look pretty legitimate and they did have pretty similar experiences to our product testers.
About 60% said yes they did notice increased energy, slight hunger reduction and it did seem to help improve weight loss. We found a couple complaints about jitters, nausea and headaches, but all of these are in line with potential side effects from the ingredients. So again this wasn’t surprising.
A few people said they’d tried similar products at a lower price point that performed better, all in all we’ll be giving a 7/10 score for aggregated customer satisfaction until more capsiplex burn reviews come in.
100mg Capsimax - Capsimax is a patented blend of capsaicinoids, which are bioactive compounds found in chili peppers (Capsicum annuum). The predominant capsaicinoids in Capsimax are capsaicin, dihydrocapsaicin, and nordihydrocapsaicin. Capsaicinoids are known to elicit a sensation of heat and spiciness in the oral cavity and gastrointestinal tract when consumed. 100mg is within the realms of the effective range, but this is in a lot of other fat burners at this dose, and the patented blend is more for marketing than really much else.
Capsaicinoids have garnered attention in the context of weight management due to their potential effects on metabolism and appetite regulation. Research suggests that capsaicinoids can increase energy expenditure through a process called thermogenesis, whereby excess calories are dissipated as heat.  Thermogenesis is primarily mediated by the activation of transient receptor potential vanilloid 1 (TRPV1) receptors located on brown adipose tissue and skeletal muscle. Stimulation of these receptors leads to the release of norepinephrine, which enhances fat oxidation and energy expenditure.
Moreover, capsaicinoids may influence appetite and satiety.  Studies have shown that capsaicinoids can suppress appetite, reduce food intake, and increase feelings of fullness. Although there is mixed evidence on this.
250 mg Innoslim - Innoslim is a patented blend of two herbal extracts: Panax ginseng and Astragalus membranaceus. Panax ginseng, commonly referred to as Korean ginseng, contains bioactive compounds known as ginsenosides, which are believed to contribute to its pharmacological effects. Astragalus membranaceus, also known as Huangqi, is an herb commonly used in traditional Chinese medicine. It contains various bioactive components, including flavonoids and polysaccharides.
Innoslim is claimed to exert its effects on weight management through the modulation of mRNA levels, leading to enhanced glucose absorption, fat burning, and increased energy production. However, the precise mechanisms of action of Innoslim and the specific interactions with mRNA remain to be fully elucidated. Limited scientific research is available regarding the weight management effects of Innoslim, and whilst ginseng has been shown to have some impact on body recomposition , that’s in larger doses (the full 250mg) so one of the ingredients here isn’t doing much heavy lifting . Realistically it’s probably dosed correctly and it’s the Astragalus that’s just in here for marketing hype. It’s an OK ingredient, and could help with a bit of extra powder in the gym as it’s been shown to increase muscle mass and impact test levels. This is where it’s really helpful for burn by capsiplex.
76mg and 4.5mg Green Tea and Green Coffee Extracts - Green tea extract is derived from the leaves of Camellia sinensis, and green coffee extract is obtained from unroasted coffee beans. Both extracts contain bioactive compounds that have been investigated for their potential contributions to weight management.
Green tea extract is rich in catechins, particularly epigallocatechin gallate (EGCG). Catechins are potent antioxidants and have been suggested to influence weight management through multiple mechanisms. EGCG has been found to increase thermogenesis and fat oxidation,  thereby promoting energy expenditure and contributing helping you lose weight. It may also modulate adipocyte metabolism, reduce fat accumulation, and inhibit the activity of enzymes involved in fat digestion and absorption.
Green coffee extract contains chlorogenic acids, which are phenolic compounds with antioxidant properties. Chlorogenic acids have been investigated for their potential effects on glucose metabolism and weight management. They may inhibit glucose absorption  in the intestines, reduce hepatic glucose production, and modulate insulin sensitivity. That said, the jury on this is still out and results have been mixed as to whether or not it will actually help you burn fat.
B-Vitamins - B-vitamins, including niacin (B3), pyridoxine (B6), and cobalamin (B12), are essential micronutrients involved in numerous metabolic processes in the body.  These vitamins participate in various enzymatic reactions and play critical roles in energy metabolism (burning fat), macronutrient breakdown, and the synthesis of red blood cells.
Niacin, in the form of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), serves as a cofactor for several enzymes involved in cellular metabolism, including those responsible for converting carbohydrates, fats, and proteins into energy. Deficiencies in niacin can impair energy production and overall metabolic function.
Pyridoxine, as pyridoxal phosphate, acts as a cofactor for over 100 enzymes involved in amino acid metabolism, neurotransmitter synthesis, and glycogen breakdown. It plays a crucial role in the metabolism of tryptophan, an amino acid involved in the synthesis of serotonin, a neurotransmitter associated with mood regulation and appetite control.
Cobalamin, commonly known as vitamin B12, is essential for DNA synthesis, red blood cell formation, and the maintenance of neurological function. It is involved in the metabolism of fatty acids and amino acids and plays a crucial role in the conversion of homocysteine to methionine, an essential amino acid. Adequate levels of vitamin B12 are important for maintaining optimal energy production and overall metabolic health. 
Iodine - Iodine is an essential trace mineral required for the synthesis of thyroid hormones, thyroxine (T4), and triiodothyronine (T3). These hormones regulate various aspects of metabolism, including basal metabolic rate, thermogenesis, and the utilization of carbohydrates, fats, and proteins for energy production.
Thyroid hormones influence metabolic processes in virtually all cells in the body, affecting oxygen consumption, heat production, and nutrient metabolism. Inadequate iodine intake can lead to impaired thyroid function, resulting in hypothyroidism, which is associated with weight gain, decreased energy expenditure, and difficulties in losing weight. That said, this is only in cases where low iodine is an issue that it’s going to be helpful and it’s not the most common deficiency. 
170mcg Chromium - Chromium is a trace mineral that plays a role in glucose metabolism and insulin action. It functions as a cofactor for insulin, facilitating its binding to receptors and enhancing insulin sensitivity. By improving insulin signaling, chromium may contribute to better glucose control and potentially aid in weight management. This is well within the effective dose range and is used in a similar dose across a lot of our top rated fat burners. It’s not the best ingredient in capsiplex, but it takes up relatively little capsule space, making it a good inclusion.
Chromium is involved in the metabolism of macronutrients, particularly carbohydrates and fats. It helps regulate blood sugar levels by enhancing the entry of glucose into cells and promoting its utilization as an energy source. This mechanism may help prevent excessive glucose accumulation and subsequent fat storage.
Additionally, chromium has been suggested to impact appetite regulation. Some studies indicate that chromium supplementation may reduce hunger, cravings for carbohydrates, and binge eating episodes. However, the scientific evidence regarding chromium's effectiveness for weight loss is mixed, and more research is needed to establish its potential benefits and optimal dosages. 
800mg L-Tyrosine - L-Tyrosine is a non-essential amino acid that serves as a precursor for the synthesis of several important neurotransmitters, including dopamine, norepinephrine, and epinephrine. These neurotransmitters play key roles in regulating mood, motivation, and cognitive function.
By influencing neurotransmitter synthesis, L-tyrosine supplementation may support cognitive performance, particularly under conditions of stress, fatigue, or sleep deprivation. It has been suggested to enhance alertness, attention, and working memory, thereby potentially aiding individuals in adhering to dietary and exercise regimens required for weight management.
Furthermore, L-tyrosine is involved in the production of thyroid hormones. Thyroxine (T4) and triiodothyronine (T3) require adequate tyrosine availability for their synthesis. Optimizing thyroid function is essential for maintaining a healthy metabolism and efficient utilization of nutrients. That said, there are far better ingredients than L Tyrosine for craving management, so this is a middle of the road “OK”, but not great inclusion. It should also be mentioned that the studies are relatively mixed on L Tyrosine. 
500mg L-Arginine - L-Arginine is a semi-essential amino acid involved in numerous physiological processes. It serves as a precursor for the synthesis of nitric oxide (NO), a molecule involved in the relaxation of blood vessels and the regulation of blood flow. Nitric oxide promotes vasodilation, which may enhance nutrient and oxygen delivery to tissues.
L-Arginine is also known to stimulate the release of growth hormone, insulin, and other substances in the body. Growth hormone plays a role in the regulation of metabolism, body composition, and muscle growth. Insulin is involved in glucose metabolism and nutrient uptake by cells.
Some studies suggest that L-Arginine supplementation may promote lean muscle mass and potentially contribute to fat burning. It is hypothesized that L-Arginine's effects on growth hormone and insulin may play a role in these outcomes. However, further research is required to establish the efficacy and safety of L-Arginine for weight management as it’s not currently very well backed. Again this is another indicator that the Capsiplex Burn supplement is really for people training hard already that are just looking to speed things up a little bit when it comes to weight loss. 
20mg Black Pepper (Piperine) - Piperine is a bioactive compound found in black pepper (Piper nigrum) that contributes to its pungent taste and aroma. Piperine has been shown to enhance the bioavailability and absorption of various nutrients and drugs by inhibiting certain enzymes in the liver and intestine. Generally speaking 10mg of this is more than enough to get the desired effects, but it’s not a particularly large amount of capsule space to waste.
|● Combines two proprietary ingredients for a powerful thermogenic fat-burning effect
|● Optimal results for shredding and preserving muscle mass may take up to two months
|● Helps regulate glucose levels for better fat loss
|● Should be taken on an empty stomach, which may be challenging for some individuals
|● Good energy boost
|● Can cause nausea and jitters for some
|● 60-Day Money Back Guarantee
|● Not the best for appetite suppression
Capsiplex Burn should be taken on an empty stomach, 30 minutes before workouts or before the first meal on off-days. No significant side effects have been reported in clinical studies of the individual ingredients. However, individuals with sensitivities to caffeine, capsaicin, or other diet pills should consult a physician before using Capsiplex Burn. Because as far as Capsiplex side effects go, jitters and an upset stomach are going to be relatively common place.
Pregnant or breastfeeding individuals should also wait before using the supplement. Capsiplex Burn is available at a price of $64.99 for a month's supply. Discounts are available for bulk purchases, with free shipping and a 60-Day Money Back Guarantee. It's a little overpriced against similar products, but not massively so, and we suspect this is so they can account for the money back guarantee as this tends to be typical of supplements offering them.
So, we've taken an in-depth look at Capsiplex Burn, a weight loss supplement with claims rooted in the properties of its key ingredient, capsaicin. It's true that some studies suggest capsaicin may play a role in metabolism and weight management, but it's important to temper expectations when it comes to any supplement. Science, while promising, hasn't yet unlocked a one-size-fits-all answer to weight loss. Nothing can substitute for the power of a well-balanced diet and regular exercise. This is why we generally prefer weight loss aids with more effective appetite suppression elements like glucomannan (which simply swells up in the stomach with one correct dose feeling like you’ve just eaten a bagel) and 5htp which is a natural hormone found in a lot of foods which plays a role in appetite.
That said Capsiplex Burn can definitely serve as a helpful aid for those wanting to speed weight loss up by 5-10% or who’ve hit a wall with shifting the last few pounds. But this is very much a couple of last lbs over a month type product, if you’re looking to get more we’d recommend something else from our best fat burners list.
Remember, healthy weight loss is a journey, not a race, and a supplement like Capsiplex Burn, if it proves effective, is only a part of a larger lifestyle approach.
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1 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088424/
2 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426284/
3 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766689/
4 - https://pubmed.ncbi.nlm.nih.gov/32379240/
5 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649093/
6 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350188/
7 - https://pubmed.ncbi.nlm.nih.gov/30074168/
8 - https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
9 - https://ods.od.nih.gov/factsheets/Iodine-HealthProfessional/
10 - https://ods.od.nih.gov/factsheets/Chromium-HealthProfessional/
11 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198440/
12 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151442/