Most of the ingredients in Gundry MD Metabolic Advanced aren't really suitable for a weight loss supplement, whilst there is some tangential evidence for things like turmeric root extract, the dose is way to low to have any impact. For joint relief it needs to be 5 times the amount here and it needs even more for metabolic issues. The mineral complex does have some value, but aside from chromium, these vitamins are mostly good for men, seeing as they can increase testosterone production and thus lower body fat. Beyond that we're left with Berberine and Cinnamon Bark which aren't exactly highlights. There are plenty of better ingredients that could've been included in a weight loss aid, and most people would be best off getting a multivitamin and one of those.
Typically what we look for in a good weight loss supplement is something that can suppress appetite, cravings and help you move more when you're in a calorie deficit (the human body subconsciously makes you move less when you diet, lessening the effects of eating less). Some ingredients can raise your metabolism, but generally speaking these effects are the lowest of the three in terms of their effectiveness, unless you have a particular vitamin deficiency raising your metabolism is the least effective of the three options.
As a result we generally recommend going for a product like instant knockout which contains glucomannan (which swells 50X larger in the stomach to about the size of a bagel making you want to eat less) and a host of energy boosting ingredients.
A quick look at Metabolic advanced amazon reviews tells one story, but if you actually look at the written metabolic advanced customer reviews that's quite different, of the 62% 5 star reviews only 2 of these are actually written and one verified at time of writing. Whereas if we look at the written reviews we have a lot more 1 star gundry md metabolic advanced reviews. We're not saying the 5 star reviews are fakes, just that it's quite easy to fake simple star reviews that don't actually include writing and there are many services that would do this for the metabolic advanced supplement. Some customers even said they gained weight whilst on Gundry's metabolic advanced supplement.
Zinc 30mg - This is far more zinc than needed for it's benefits, and even then it's only beneficial as a dietary supplement for men when it comes to weight loss. And that's because it plays an important role in the production of testosterone production. A zinc deficiency for men can lead to significant weight gain due to this issue as a metabolic slowdown is part and parcel of low t. It does have some impact on women, but it's substantially less important to a healthy metabolism.
Selenium (as Selenomethionine) 70mcg - There is some evidence for selenium's use in gundry md metabolic advanced although the evidence is shaky. The problem with the selenium studies is that they are corralation studies rather than clinical trials. People with less selenium in their diet do have higher BMI, but that in and of itself is also generally true of people who simply have healthier diets and is true of most vitamins and minerals. It is true that low selenium levels can cause metabolic syndrome, however, it is a very rare deficiency.
Chromium (as Chromium Picolinate) 100mcg - This is perhaps the best mineral inclusion in gundry md metabolic advanced, there are several trials which suggest that chromium supplementation can lead to minor difference in weight loss whilst dieting vs a control group. Whilst it was only a difference of about 5% more every 6 weeks in morbidly obese women it is still a statistically noticeable difference. And deficiency in chromium can cause metabolic syndrome, although like selenium this is not a common issue. Restricting calories would ultimately be far more effective than chromium dietary supplements.
Cinnamon Bark 250mg - So cinnamon can be useful in losing weight, just in much, much greater volumes than 250mg. In fact you need 2g per pound of body weight of cinnamon extract for it to be effective. It resulted in the trial participants losing 2.59% more body weight than those without. The Gundry md metabolic advanced dietary supplement does not contain nearly enough to be of any use at all.
Berberine HCl (Berberis aristata bark and root extract) 250mg - Berberine does have an effect on blood glucose levels, which has a loose connection with weight loss. In terms of Berberine having an impact on the development of fat cells, which we suspect is the reason for its inclusion in Gundry md metabolic advanced, this has only been shown in rodent models. And unfortunately most rodent studies do not translate to working for humans. Then there is also the fact that like cinnamon bark a human sized dose would be in grams, not milligrams even if it does prove to be effective.
Turmeric Root Extract (95% Curcuminoids) 100mg - Curcuminoids do have an effect on metabolic syndrome specifically, although this was in a higher dose 1500mg. As for any other benefits from the turmeric root extract it needs to be dosed at above 500mg, an argument could be made that it's anti inflammatory effects could help people train harder thus lose weight faster or support joints for overweight people engaging in exercise. But, still this is not a reason to buy metabolic advanced as the dose is far too low for it's health benefits.
BioPerine 10mg - Bioperine is a fine inclusion in pretty much any supplement, it does little to combat weight gain or overall health, but it does help the body absorb other vitamins and minerals so this is a fine inclusion in gundry md metabolic advanced.