S-Adenosyl-L-Methionine (SAMe) is a naturally occurring chemical in the body that has been studied for its potential benefits in treating various conditions, including depression, osteoarthritis, and liver diseases. While SAMe has shown promise in some studies, the evidence regarding its effectiveness is not conclusive.
SAMe is available as a dietary supplement and has been studied for its potential benefits in conditions such as depression, osteoarthritis, liver diseases, and more. While SAMe is naturally produced in the body, supplementation may be necessary in cases of deficiency or to support specific health concerns. 
The short answer: SAMe takes around 1-2 months to be effective when consumed in doses of around 1200mg.
So, How Long Does SAMe Take To Work?
There are a few variables, including dosage and method of delivery.
Some studies used injected SAMe, which may not have the same effects as SAMe taken as a dietary supplement. Therefore, it is important to consider these factors when interpreting the results and determining the timeline for experiencing the effects of SAMe on joint health.
In studies evaluating the effectiveness of SAMe for joint health, participants typically took the supplement for several weeks or months. However, it is important to note that the studies conducted so far have had limitations, including small sample sizes and varying dosages of SAMe.
Most of the effective trials used 1200mg of SAMe and checked results after at least 8 weeks. Which would suggest that in most use cases results should be apparent within this time frame.
However, several trials showed results after a period of 1 month. But, it should be noted that due to the nature of SAMe itself, a build up period is required. Meaning that it should certainly take weeks to become effective when consumed orally.
There is some evidence that this is quicker when injected, however, it is none conclusive.
There is less evidence to speculate on the working time of lower doses of SAMe, with 400-600mg rarely being used in notable trials.
The Role of SAMe in Joint Health
SAMe has been investigated for its effects on joint health, particularly in conditions like osteoarthritis. Osteoarthritis is a degenerative joint disease characterized by the breakdown of cartilage, leading to pain, stiffness, and functional limitations. Research has explored the potential of SAMe in reducing pain, inflammation, and improving joint function in individuals with osteoarthritis.
Osteoarthritis and SAMe
Several studies have examined the use of SAMe in individuals with osteoarthritis. These studies have compared SAMe with nonsteroidal anti-inflammatory drugs (NSAIDs) or placebos in patients with knee, hip, or spine osteoarthritis. The results have been mixed, with some studies showing comparable pain relief and improvement in joint function between SAMe and NSAIDs, while others did not consistently demonstrate significant benefits. 
One review of studies found that SAMe was as effective as NSAIDs in reducing functional limitations caused by osteoarthritis. Additionally, SAMe was found to have a similar effect to NSAIDs in terms of pain reduction. However, more research is needed to establish the definitive effectiveness of SAMe for osteoarthritis. 
How Does SAMe Work?
The exact mechanism by which SAMe may benefit joint health is not fully understood. However, it is believed that SAMe might help promote cartilage repair and reduce inflammation in the joints. SAMe has been shown to stimulate the production of collagen and proteoglycans, which are key components of cartilage. By supporting cartilage health, SAMe may help alleviate the symptoms associated with osteoarthritis. 
Moreover, SAMe has been studied for its potential pain-relieving properties. It is thought to modulate the transmission of pain signals in the central nervous system, leading to a reduction in pain perception. This mechanism may contribute to the pain relief experienced by individuals with osteoarthritis who take SAMe.
Clinical Studies on SAMe and Osteoarthritis
A number of well-designed clinical studies have investigated the use of SAMe for osteoarthritis. These studies have evaluated the efficacy of SAMe compared to placebo or NSAIDs in terms of pain relief, improvement in joint function, and other relevant outcomes.
One study compared the effectiveness of SAMe to celecoxib, a type of NSAID, for pain control and functional improvement in individuals with osteoarthritis. The study found that SAMe was as effective as celecoxib in relieving pain and improving physical function, although the onset of action was slower for SAMe. 
In another trial, SAMe was compared to nabumetone, an NSAID, in individuals with knee osteoarthritis. Both groups reported improvements in pain, stiffness, and function, with no significant differences between the two treatments. 
However, not all studies have consistently shown significant benefits of SAMe for osteoarthritis. Some studies comparing SAMe to a placebo did not find consistent evidence of SAMe's effectiveness. The conflicting results highlight the need for further research to fully understand the potential benefits of SAMe for individuals with osteoarthritis. 
Safety Considerations and Side Effects of SAMe
SAMe is generally considered safe for most individuals when taken as directed. However, it is important to be aware of potential side effects and interactions with other medications or supplements. Common side effects of SAMe include nausea, restlessness, headaches, dry mouth, and stomach upsets. These side effects are usually mild and infrequent.
It is worth noting that individuals with bipolar disorder should exercise caution when considering SAMe supplementation. SAMe may potentially worsen symptoms of mania in individuals with this condition. It is advisable to consult with a healthcare provider before taking SAMe if you have bipolar disorder.
Additionally, SAMe may interact with certain medications, such as antidepressants and levodopa (used for Parkinson's disease), as well as dietary supplements that increase serotonin levels. Individuals taking these medications or supplements should consult with their healthcare provider before starting SAMe supplementation.
SAMe for Other Joint Conditions
While SAMe has primarily been studied for its effects on osteoarthritis, research has also explored its potential benefits for other joint-related conditions.
Fibromyalgia is a chronic condition characterized by widespread pain, fatigue, and tenderness in specific tender points throughout the body. SAMe has been investigated as a potential treatment for fibromyalgia, with some studies suggesting it may help reduce pain, fatigue, morning stiffness, and depressive symptoms associated with the condition. 
However, the evidence for SAMe's effectiveness in fibromyalgia is limited, and more research is needed to establish its role in managing the symptoms of this condition.
1 - https://www.nccih.nih.gov/health/sadenosyllmethionine-same-in-depth
2 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387830/
3 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061276/
4 - https://pubmed.ncbi.nlm.nih.gov/18464034/
5 - https://files.nccih.nih.gov/s3fs-public/SAMe_08-11-2015.pdf
6 - https://pubmed.ncbi.nlm.nih.gov/19821403/
7 - https://pubmed.ncbi.nlm.nih.gov/1925418/