Resveratrol and Weight Loss

Resveratrol may not be the first supplement that you think of when it comes to weight loss. Generally speaking it’s more known for brain health or as an anti inflammatory, but the studies are actually quite interesting when it comes to Resveratrol weight loss. And whilst there is some inconsistency in the results, there is a clear pattern that begins to emerge when we look at dosing. And that is that whilst it seems you need a lot more resveratrol for weight loss than for it’s other benefits, there may well be something to this.

Understanding Resveratrol

Resveratrol is mostly known as an antioxidant compound that is usually extracted from red grape skins. It gained a lot of popularity in the 90s when it began being studied for it’s anti aging effects. There have been a lot of studies on the compound since, included weight loss, which we’re looking at today, although you can read more about it in general here.

Resveratrol and Weight Loss: The Studies

The most commonly cited publication on resveratrol and weight loss is Tabrizi et al.'s meta-analysis. The analysis included 36 randomly controlled trials and did suggest there are notable impact on BMI and lean muscle mass.  [1]

However, the evidence supporting these claims is somewhat limited with most studies conducted on animals or in a small number of human trials.

There has been a further review of nine studies conducted over a 15-year period found no significant changes in body weight, BMI, or fat mass among individuals who supplemented with resveratrol. [2]

The issue is that both of these meta analysis could be considered somewhat cherry picked. But, it is worth noting that across both a trend does appear.

And that is quite simply that if you shift the minimum dosing to 800mg, then the overwhelming majority of human trials show positive weight loss against placebos. [3]

Whilst the weight loss was moderate it was definitely statistically significant in this case.

It’s also worth noting that no hormonal differences were observed in the trials suggesting any difference to weight loss caused by resveratrol was not due to hormonal changes. [4]

How Else Could Resveratrol Aid Weight Loss

One area of research that has piqued interest is the potential of resveratrol to improve physical endurance. Studies conducted on animals have shown promising results, with resveratrol appearing to activate enzymes that help muscles use oxygen more efficiently. Which could of course help weight loss, however, most of the current evidence is anecdotal or as we mentioned on animals. Resveratrol does however seem to have a benefit for joint health, which context dependant could also help with weight issues. [5]

Resveratrol Side Effects

Resveratrol is generally considered safe. The U.S. National Library of Medicine suggests that daily doses of up to 1500mg for up to three months are possibly safe, but higher doses may cause stomach problems.

It can like almost all supplements cause mild nausea and gas.

So, Does Resveratrol Help You Lose Weight?

Possibly, it does look like there’s something here that warrants further study, however, the trials that have been done so far aren’t of particularly high quality which does put a slight damper on any current excitement around using resveratrol in this way. Although it does seem the supplement has a lot of other uses.

References

1 - https://pubmed.ncbi.nlm.nih.gov/30421960/

2 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002514/

3 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357128/

4 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143620/s

5 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579386/

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