Published Sept 13th 2023
Fact Checked By Dr Mark Watson
The human body triggers inflammation to protect a damaged area as it attempts to repair it. The issue is, the inflammatory response often ends up being far worse that the actual damage, and the immune system can even erroneously trigger it, which causes chronic issues like arthritis and inflammatory bowel disease.
Acute inflammation can lead to chronic pain, so people will seek pain relief from anywhere they can. Many doctors prescribe nonsteroidal anti inflammatory drugs to help reduce inflammation and pain, but research suggests that they aren't always the best option, as they can cause side effects or other health conditions.
That's why dietary supplements made of natural ingredients with anti inflammatory properties are now very popular, as they can reduce inflammation and pain in a similar way, while product manufacturers addressed safety concerns to ensure they will not cause any side effects. The only issue is knowing which one to use.
That's why we have made the following guide to the best natural anti inflammatory compounds, so you can ignore products that contain useless ingredients like aged garlic extract and select one of the most potent anti inflammatory supplements on the market today and enjoy all of the many health benefits it has to offer.
If you're looking for a supplement that contains most of these then we generally recommend FlexAgain which has a lot of these in the correct doses and we currently rank as the best joint supplement on the market, you can read more about it here .
Omega 3 fatty acids are a type of healthy fat that comes in three forms, which are ALAs (alpha-linoleic acid), EPAs (eicosapentaenoic acid), and DHAs (docosahexaenoic acid).
ALAs are found in things like beans, nuts, pulses, seeds, plant oils, and seaweeds, while EPAs and DHAs are almost only ever seen in fatty fish, fish oil, and some other seafoods. This makes ALAs the best omega 3 fatty acids to take for people who don't want to use fish oil supplements.
All three types provide potent anti inflammatory effects that help to protect the bones, muscles, joints, and connective tissues from damage, repair damage that has already been done, and keep the joints flexible, lubricated, mobile, and functioning, while boosting the health and functions of the nerves as well (1) .
Glucosamine is a natural compound that is found in human cartilage and shellfish, and which can also be produced in a lab. Its powerful anti inflammatory properties are infamous, and the Arthritis Foundation even rank it as one of the best natural supplements to combat arthritis symptoms of all kinds.
Glucosamine supplements will help relieve pain in the joints at the same time as preventing or slowing collagen degradation. As collagen is the main component of cartilage, the tissue that stops your bones from rubbing together, this will improve and restore joint health and functions (2).
Chondroitin is another substance naturally produced by the human body that is one of the main components of cartilage. It is thought to relieve virtually all of the joint pain and symptoms caused by arthritis and is said to be especially useful for combatting knee osteoarthritis.
It also has the ability to help make stiff joints mobile again, improve your natural collagen production, and repair any previously damaged joints. Complementary and integrative health research suggests that it is also at its most potent when used in dietary supplements that also contain glucosamine (3).
MSM (methylsulfonylmethane) is an compound found in some fruits, plants, and vegetables that is high in sulphur and proven to produce a powerful antioxidant and anti inflammatory effect.
It can provide a variety of health benefits, such as reducing inflammation and arthritis symptoms and boosting the health and functions of the joints.
Scientific evidence also shows that it can enhance the efficacy of an anti inflammatory supplement that contains one or both of chondroitin and glucosamine as an active ingredient as well (4).
Turmeric extract is a spice made from the roots of the curcuma longa plant that has been used in ayurvedic medicine for centuries, as well as in many other traditional medicines around the world. This is due to it containing a chemical called curcumin, which has potent antioxidant and anti-inflammatory properties.
Curcumin supplements can neutralise free radicals, prevent oxidative stress or damage, reduce inflammation, relieve joint and muscle pain, repair damaged joints, and promote the growth of healthy cells and connective tissues (5).
Ginger extract is a natural antioxidant that produces potent anti-inflammatory effects and can prevent oxidative damage and stress and help keep the joints strong and healthy.
It then also offers a range of other health benefits, such as reducing the risk of heart disease and blood clots, preventing gut inflammation and stomach pain, boosting metabolism and nutrient absorption, and making the ingredients in a blood thinning medication easier to absorb and more effective (6).
Blue galangal extract is made from the roots of a plant native to south Asia that is known for its antioxidant properties. It can reduce inflammation and joint pain, boost nervous system and immune system health and functions, and prevent future joint damage and inflammation, or the development of chronic diseases.
It is also said to make many of the ingredients in blood thinner medications easier to absorb and more effective, while it works especially well when used in an anti inflammatory supplement that also contains ginger extract (7).
Bromelain is an enzyme most often found in pineapples that has the ability to reduce even chronic inflammation, muscle soreness, and joint degradation and pain, boost gut and digestive health and functions, and aid the metabolism of amino acids.
Some randomized controlled trials also show that it may be a promising method of preventing respiratory issues and heart disease and boosting the health and functions of the immune system (8).
Resveratrol is a substance mainly found and extracted from grapes and grapevines, but which is also present in almonds and some berries as well.
It has long been used in traditional medicines throughout Asia, due to its powerful antioxidant and anti-inflammatory properties. It can ease even chronic inflammation, prevent oxidative damage, treat the symptoms of arthritis, and provide many other effects that are extremely beneficial to human health (9).
Boswellic acid is a compound found in the boswellia serrata trees in India and the Punjab region of Pakistan. It has been used in traditional medicines worldwide for decades, due to its ability to relive inflammation and pain throughout the body (10).
There are also claims that it can alter the body's response to damage, preventing chronic inflammation from occurring and allowing it to be used as a treatment for all kinds of arthritis.
Vitamin d is a fat soluble vitamin that benefits the human body in countless different ways.
It boosts digestion, nutrient break down and absorption, energy levels, protein synthesis, bone, muscle, skin, tooth, and immune system health and functions, cell division, blood calcium levels, and your overall health, while preventing fat storage and weight gain.
The primary reason for its presence in anti inflammatory supplements though, is to prevent you from becoming vitamin d deficient and developing the issues that accompany it. This includes having a poor immune system, weak joints and bones, and very low testosterone levels (11).
Green tea extract is rich in an antioxidant catechin called EGCG, which can reduce inflammation, ease joint and muscle pains, and prevent oxidative stress or damage from occurring. The benefits that green tea can offer the human body even extend beyond reducing inflammation though.
Green tea can also boost heart, blood vessel, and brain health and functions, reduce the risk of high blood sugar or type 2 diabetes, improve weight loss and your energy levels, and help the immune system combat various diseases (12).
The only issue with green tea is that it does contain a small amount of natural caffeine, so it may not be suitable for people who are sensitive to stimulants. That said, it is a very small amount so it should not pose too much of an issue for most people.
The best anti inflammatory supplement on the market today is FlexAgain and it is not particularly close. Made by FA Nutra, it contains optimal doses of numerous proven ingredients, which allows it to effectively treat and prevent inflammation, without causing any side effects.
The FlexAgain formula contains all of the compounds we have already looked at except for green tea, as it boasts omega 3 fatty acids, ginger extract, blue galangal extract, bromelain, curcumin extract, resveratrol, glucosamine sulfate, chondroitin sulfate, MSM, and boswellic acid, and vitamin d, as well as vitamin k.
As we have already established, this means it can protect the cartilage and stimulate its growth, aid joint lubrication and repair, ease arthritis pain and symptoms, relieve joint swelling and pain, reduce and treat inflammation and damage, and keep the bones, muscles, skin, and teeth strong and healthy.
It can then also boost gut, heart, lung, brain, and immune system health and functions, prevent fat storage, increase energy levels and protein synthesis, promote cell division and normal blood calcium levels, prevent c reactive protein production, and help improve the overall health of your body.
The ingredients can even manage to do all of this while working in perfect synchronicity with each other, making the effects even more potent.
The one new ingredient, Vitamin k, can protect the blood vessels, bones, and cartilage from damage and reduce the risk and symptoms of arthritis on its own. However, it is perhaps most useful for its ability to make other fat soluble vitamins, such as vitamin d, easier to absorb and more effective (13).
The incredibly diverse range of ingredients it contains, as well as the countless benefits that it offers, means FlexAgain is a fantastic anti inflammatory supplement for people who are trying to combat or prevent virtually any type of inflammation.
It is also completely free from fish oil, which is an ingredient many people try to avoid, and is manufactured in FDA registered and cGMP certified facilities, which should give potential buyers complete confidence that the product has been produced to the highest quality, so can safely deliver maximum results.
You combine this with the full 90 day money back guarantee that is offered on all purchases if you feel that it is not working, and there really is no reason for people who are shopping for anti inflammatory supplements not to give FlexAgain a try and see just how effective it is for themselves.
Studies on complementary and integrative health show that natural anti inflammatory supplements will help fight inflammation and relieve pain just as well as prescription drugs. Not only that, but they will do so while not putting you at risk of experiencing side effects or developing complications like chronic kidney disease.
The very best natural anti inflammatory compounds will even be able to provide additional benefits, like the ability to combat ulcerative colitis, heart disease, liver disease, high blood sugar, and metabolic syndrome, boost brain health, promote healthy blood vessels, and even reset the body's immune response.
As for what the best anti inflammatory supplement is, for most people the answer is easily FlexAgain. With all its ingredients optimally dosed and its anti inflammatory benefits and health claims backed up by more research than you would ever need, it is the safest, most effective way to fight inflammation you will find.
Dr Mark Watson is the founder of Center TRT, having graduated from stamford more than 20 years ago, he is an expert in the field of supplemental health, focusing on long term benefits of complimenary treatment. View Profile